Donte DiVincenzo will not play Friday night when the Timberwolves visit Madison Square Garden for a matchup with Karl-Anthony Towns and the Knicks. His absence could pose significant challenges for Minnesota.

Karl-Anthony Towns likely is the player the Knicks can least do without, especially with Mitchell Robinson still unable to practice.

The Knicks' Karl-Anthony Towns (thumb) is questionable for Friday's game against the Timberwolves, who will be without starter Donte DiVincenzo (toe).

The 27-year-old guard has flirted with triple doubles in two of Minnesota’s last three outings. DiVincenzo tallied 28 points, nine assists, six rebounds, one steal and zero turnovers in the Wolves’ loss to the Warriors on Wednesday, making him the first player in franchise history to post such a line.

Karl-Anthony Towns of the Knicks has a bone chip in his right thumb, but is expected to try to play through the injury.

Knicks center Karl-Anthony Towns is questionable to face his former team Friday with a sprained right thumb, while Minnesota’s Donte DiVincenzo will miss his return to Madison Square Garden with a toe injury.

Donte DiVincenzo, a Knicks hero of last season’s playoffs, has been ruled out of Friday’s MSG return because of a sprained toe, the Timberwolves announced. It’ll represent the durable DiVincenzo’s first DNP of the season for the T’wolves and puts a damper on an anticipated matchup between offseason trade partners.