Manchester United and Southampton FC square off Thursday in their second matchup in the Premier League this season after Manchester United took the first game 3-0. It starts at 3:00 PM ET on

Tonight's Premier League clash between United and Southampton will be shown live in the UK on TNT Sports. Coverage will begin at 7pm - one hour before kick-off - and conclude at 10.30pm. The game is also available to be streamed live on the Discovery+ app and website.

Manchester United hope to win their first Premier League match in a month when they host last-place Southampton.

Southampton under Ivan Juric are very different to the way they played under previous boss Russell Martin because most of the time they just lump it forward now, and they are far more direct.

Man United have been promising with their performances over a few weeks and will hope to avoid any upset when they host the Saints at Old Trafford this time.

Check out our Manchester United vs. Arsenal how to watch guide to learn when they play and what free live streams are available ahead of kickoff.

The best betting opportunity comes from the player card markets at Old Trafford as this clash combines the best top-flight referee for cards with the side possessing the poorest discipline.

Southampton make the long trip to Manchester United in the Premier League this evening.The Saints are rooted to the bottom of the Premier League table and have won just six points since promotion.